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KMID : 0356720080240020091
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Journal of the Korean Society of Coloproctology
2008 Volume.24 No. 2 p.91 ~ p.99
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Clinical Significance of E-cadherin and beta-catenin Complex Expression in T2 Colorectal Cancer
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Kim Jin-Soo
Ko Yong-Taek
Hur Hyuk
Min Byung-Soh
Kim Nam-Kyu
Sohn Seung-Kook
Cho Jang-Hwan
Ahn Joong-Bae
Kim Ho-Guen
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Abstract
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Purpose: Expression of adhesion molecules is significantly correlated with the invasion and the metastasis of colorectal cancer. The aim of this study is to identify the importance of the expressions of E-cadherin and beta-catenin as a prognostic factor in T2 colorectal cancer.
Methods: Forty-five cases of primary T2 colorectal cancers were selected between February 1997 and February 2000. We evaluated the membranous expressions of E-cadherin and beta-catenin by using immunohistochemisty and analyzed the relationship with various clinico- pathologic parameters.
Results: Loss of membranous E- cadherin was significantly associated with histologic differentiation (P=0.023), vascular invasion (P＜0.001), lymphatic invasion (P＜0.001), and lymph-node metastases (P=0.001). Similar patterns were observed in the expression of beta-catenin. The correlation between the E-cadherin and the beta-catenin expressions was statistically significant (P＜0.001). In the multivariate analysis, neither the loss of expression of E-cadherin nor beta-catenin is a risk factor affecting lymph-node metastasis in T2 colorectal cancers. However, there were significant differences in the 5-year disease-free survival rates between the positive (±, ＋) and the negative (-) expression groups of E-cadherin and beta-catenin (P=0.015, 0.03).
Conclusions: This study suggests that loss of membranous expression of E-cadherin and beta-catenin molecules correlates with poor prognostic factors and indicates invasion and metastasis in T2 colorectal cancer, which, therefore, might be predictive of short survival in these patients.
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KEYWORD
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E-cadherin, beta-catenin, Colorectal cancer, Lymph-node metastasis
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